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KMID : 0360220110520030345
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Journal of the Korean Ophthalmological Society
2011 Volume.52 No. 3 p.345 ~ p.349
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Comparison of the Effects Between Bevacizumab and Mitomycin C on the Survival of Fibroblasts
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Kim Sin-Hoo
Kim Jae-Woo
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Abstract
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Purpose: To compare the antiproliferative effects between bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF), and mitomycin C in human Tenon’s capsule fibroblasts.
Methods: Primarily cultured human Tenon’s capsule fibroblasts were exposed to 0, 25, 50, 100, and 200 μg/ml bevacizumab and mitomycin C, and incubated for 5 days. Cellular survival and production of nitric oxide were assessed by MTT assay and Griess assay, respectively.
Results: Bevacizumab showed antiproliferative effects only at high concentrations (200 μg/ml) and revealed much less effect on the cellular survival compared to mitomycin C. In addition, bevacizumab did not affect the production of nitric oxide.
Conclusions: The antiproliferative effect of bevacizumab is much lower than mitomycin C in human Tenon’s capsule fibroblasts.
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KEYWORD
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Antiproliferation, Bevacizumab, Fibroblast, Mitomycin C
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